In order to study the relations between the immunological features and the sensitivity for pathogen in FMMU albino guinea pigs, the FMMU albino guinea pigs and pigment ones were infected with Eperythrozoon, and the immunological function were measured. The results are as follows: FMMU albino guinea pigs were more easily infected with Eperythrozoon than the pigment ones. The closed colony FMMU albino guinea pigs had its unique immunological features, its RBC immunological function was weaker than that of pigment ones. They were more easily infected with the pathogen and can be used better to be made into infected animal models than the pigment.