Abstract:Gout is a metabolic disease characterized by a significant hyperuric emia. In recent years the incidence of gout is rapidly increasing along with the development of China. Therefore, the prevention and treatment of gout aroused g reat interests among medical researchers. However, there is still a lack of suit able and reliable experimental animal models of gout and hyperuricemia. This art icle is a brief overview of recent advances in how to establish animal models of gout and hyperuricemia, and an introduction of own work and experiences of the authors, which could be beneficial in future research.