Abstract:Objective To study the activation extent of reactive astrocytes in br ain of PDAPP transgenic mice. Method\ The activity degree of reactiv e astrocytes in brains of PDAPP transgenic mice was compared with that of C 5 7 /BL non-transgenic mice through detecting the expression of (glial fibrillar y acidic protein(GFAP) on reactive astrocytes using immunohistochemistry. Results\ The levels of GFAP expression on reactive astrocytes in brains fr om PDAPP tra nsgenic mice was significantly higher than that of C 57 /BL non-transgenic mice. Conclusion\ There could be significant neuroinflammation in brain of PDAPP transgenic mice.