Increased Activation of Reactive Astrocytes in Brain of PDAPP Transgenic Mice
  Revised:May 16, 2003
View Full Text  View/Add Comment  Download reader
DOI:
KeyWord:Alzheimer's disease,Transgenic mouse,Astrocy tes,Glial fibrillary acidic protein
ZHANG Jian-min ,WANG Hong ,HUANG Lan ,ZHU Hua ,GAO Hong ,LIU Li ,QIN Chuan ,HE Wei
ZHANG Jian-min 1,WANG Hong 2,HUANG Lan 3,ZHU Hua 3,GAO Hong 3,LIU Li 3,QIN Chuan 3,HE Wei 1
Hits: 592
Download times: 0
Abstract:
      Objective To study the activation extent of reactive astrocytes in br ain of PDAPP transgenic mice. Method\ The activity degree of reactiv e astrocytes in brains of PDAPP transgenic mice was compared with that of C 5 7 /BL non-transgenic mice through detecting the expression of (glial fibrillar y acidic protein(GFAP) on reactive astrocytes using immunohistochemistry. Results\ The levels of GFAP expression on reactive astrocytes in brains fr om PDAPP tra nsgenic mice was significantly higher than that of C 57 /BL non-transgenic mice. Conclusion\ There could be significant neuroinflammation in brain of PDAPP transgenic mice.
Close
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=92588EB9172732CD6A144B0A7EE7D20F9148A1F94E9A2C33CB7898EE382367D1DC428CD4A2686165A6B1659C5DBA412C6F022D4E28B62161EB15303B2F66DDEF3E494702059036BD58CE9EBE7AFA0F32&pcid=&cid=&jid=&yid=D0E58B75BFD8E51C&aid=2649840&vid=&iid=CA4FD0336C81A37A&sid=13553B2D12F347E8&eid=A04140E723CB732E&fileno=20040110&flag=1&is_more=0"> var my_pcid=""; var my_cid=""; var my_jid=""; var my_yid="D0E58B75BFD8E51C"; var my_aid="2649840";