Chronic obstructive pulmonary disease(COPD) is an important chronic respiratory system disease with high morbidity and mortality.It mainly consists of chronic bronchitis and pulmonary emphysema,characterized by slow progressive development.The patients with COPD have weak work ability and poor life quality. Numerous researches both at home and abroad are focused on the potential pathogenesis of COPD in recent years.However,until now the progress in COPD research is still very slow.The main reason for this is not only multiple causes but also complex pathogenesis of COPD.The aim of this review is to sumup the COPD animal models and to objectively evaluate the advantages and disadvantages of each model.