|
| Isolation of Babesia microti -like Parasites from Blood Donors through hu-RBC-SCID Mice |
| Revised:May 22, 2003 |
| View Full Text View/Add Comment Download reader |
| DOI： |
| KeyWord:Mice, SCID,Models, Animal,Babesiosis |
| WEI Qiang,TSUJI Masayoshi,ISHIHARA Chiaki |
| WEI Qiang1,TSUJI Masayoshi2,ISHIHARA Chiaki2 |
| Hits: 412 |
| Download times: 0 |
| Abstract: |
| Objective To isolate and identify piroplasms from a Japanese blood donor by using NOD/shi-scid mice. Methods The donor's blood specimen was inoculated into NOD/shi-scid mice, whose circulating erythrocytes(RBC) had been replaced with human RBCs(hu-RBC-SCID mice). Results Parasites proliferated within the human RBCs in the mice, resulting in a high level of parasitemia, and the parasites were related closely to %Babesia microti.% Conclusion Our results demonstrated the usefulness of hu-RBC-SCID mice for isolation of parasites from human and for maintenance of the parasite infectivity for human RBCs. |
| Close |
|
|
|