Isolation of Babesia microti -like Parasites from Blood Donors through hu-RBC-SCID Mice
  Revised:May 22, 2003
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KeyWord:Mice, SCID,Models, Animal,Babesiosis
WEI Qiang,TSUJI Masayoshi,ISHIHARA Chiaki
WEI Qiang1,TSUJI Masayoshi2,ISHIHARA Chiaki2
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      Objective To isolate and identify piroplasms from a Japanese blood donor by using NOD/shi-scid mice. Methods The donor's blood specimen was inoculated into NOD/shi-scid mice, whose circulating erythrocytes(RBC) had been replaced with human RBCs(hu-RBC-SCID mice). Results Parasites proliferated within the human RBCs in the mice, resulting in a high level of parasitemia, and the parasites were related closely to %Babesia microti.% Conclusion Our results demonstrated the usefulness of hu-RBC-SCID mice for isolation of parasites from human and for maintenance of the parasite infectivity for human RBCs.
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