Objective To compare the immunological features of FMMU albino guinea\|pig and pigment ones, including the serum content of complement and immunoglobulin, lymphocyte transformation rate and immunological function of erythrocyte.Methods\ The content of immunoglobulin(IgG,IgA,IgM), complement 3(C3), complement 4(C4) and the total activity of complement of two groups were measured by Clinical Chemistry Analyzer; the lymphocyte transformation rate of FMMU albino guinea\|pig and pigment ones were measured by lymphocyte transformation test; RBC\|C3bR rosette \|forming rates of two groups were measured by red cell C3b receptor rosette test. Results\ The serum content of immunoglobulin(IgG,IgA,IgM), complement 3(C3), complement 4(C4) and the total activity of complement of the FMMU albino guinea pigs were lower than those in pigment ones. The transformation rate of the FMMU albino guinea pigs was a little lower than that of pigment ones. There was no significant difference in the values of RBC\|C3bR rosette\|forming rate between FMMU albino guinea\|pigs and pigment ones, but RBC\|IC rosette\|forming rate was lower than that in pigment ones. Conclusion\ Closed colony FMMU albino guinea\|pigs have their unique immunological features, and their immunological function is weaker than that of pigment ones as a whole.