Study on the Difference of the Chemical Mediator-Induced Airway Reactivity between Two Strains of Guinea Pig
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Q95-33

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    Abstract:

    Objective To study the sensibility of airway of new strain Zmu 1:DHP guinea pig inhaling the chemical mediator from the respiratory tract. Method With increasing concentration, histamine (His) and acetylcholine (Ach) were breathed in respectively by the animals, and the time and the mediator concentration of the asthma onset were recorded in comparison with DHP guinea pig. Results When inhaling the gas of 0 02% His, the respiratory rate and the volume of flow of Zmu 1:DHP guinea pig were higher significantly than DHP guinea pig ( P <0 05). When 0 04% His, both of the strains were not divergent remarkably in asthma ( P >0 05). When 0 06% His, these of Zmu 1:DHP guinea pig were lower notably than DHP guinea pig ( P <0 05). Conclusion The sensibility of Zmu 1:DHP guinea pig is higher significantly to the reaction of asthma than DHP guinea pig when the lower His gas is inhaled.

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  • Received:
  • Revised:April 07,2001
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