Objective To replicate the acute hypoxic ischemic brain damaged animal model.Methods The uterine arteries of full\|term pregnant mice were ligated to interrupt the blood supply by cesarean section.The baby mice with asphyxia were observed for their physical and behavior development and their pathological changes in their brains.Results With prolonging the duration of interrupting the blood supply,the morbidity in fetal mice increased.The relationship between those was positive linear correlation ( P <0.05).The development of body weight and behavior in baby mice was reatrded.The pathologic changes in the brains were apparent,which were similar to the neonatal.Conclusion The animal model can be used for the study of the neonatal hypoxic ischemic brain damage.\;