Severe fever with thrombocytopenia syndrome virus(SFTSV)is a novel Bunyavirus which was first reported in China in 2009. Tick is its important reservoir host and vector. Both wild and domestic animals can be naturally infected. IFNAR-/- immunodeficient mice are ideal experimental animal models. In this article, the research result of animal infection and animal models of SFTSV are summarized, which provide the basis for the control of SFTSV natural epidemic and for animal experiments.