Objective To promote resource information sharing in the field of laboratory animals and meet the needs of various levels and research purposes, national infrastructure for an animal model resource platform was established to meet the needs of both the supplier and customer. Methods We issued a collection letter for laboratory animal and animal model resources, collected laboratory animals and animal model resources nationwide, and supplemented related resources from the literature and public databases. Results The national infrastructure for an animal model resource platform systematically collected and arranged laboratory animal resources, animal models, and related product information, covering the development, identification, evaluation and application of laboratory animals and animal models, as well as exclusive reagents, instruments, and equipment for animal experiments, and science and technology outsourcing services based on animal experiments. We promoted resource sharing through the network platform and provided data support for drug screening and treatment. Conclusions In this study, we established national infrastructure for an animal model resource platform to provide one-stop services such as enquiries for laboratory animals and relevant resource information, release of information on supply and demand units, and display of detailed information to provide high-quality scientific and technological laboratory animal and animal model resource sharing services for scientific and technological innovation and social development.