| 胡海坚,张旭.斑马鱼动物模型在眼科中的应用研究进展[J].中国实验动物学报,2022,30(7):966~972. |
| 斑马鱼动物模型在眼科中的应用研究进展 |
| Research progress on the application of zebrafish animal models in ophthalmology |
| 投稿时间：2022-05-11 |
| DOI：10. 3969 / j.issn.1005-4847. 2022. 07. 012 |
| 中文关键词: 斑马鱼 动物模型 眼科疾病 药物 |
| 英文关键词:zebrafish animal models ophthalmic diseases drugs |
| 基金项目: |
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| Author Name | Affiliation | | HU Haijian | Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science,Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Branch of National Clinical Research Center for Ocular Diseases, Nanchang 330006, China | | ZHANG Xu | Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science,Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Branch of National Clinical Research Center for Ocular Diseases, Nanchang 330006, China |
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| 中文摘要: |
| 斑马鱼已成为一种广泛用于研究脊椎动物发育、疾病遗传机制和药物毒理学的模式生物。 由于斑马鱼与人类的眼睛在形态、生理、功能和基因表达的相似性,胚胎容易获得、发育很快而且易于观察和操作等特点,使其成为人类眼科疾病的良好的动物模型,并为进一步探究疾病发生机制和治疗方法提供新的见解。 本综述将介绍斑马鱼的眼部特征、斑马鱼动物模型在眼科疾病及药物疗效、药物眼毒性评估中的应用。 |
| 英文摘要: |
| Zebrafish has become a widely used model organism to study vertebrate development, genetic mechanisms of diseases, and drug toxicology. There is high similarity in the morphology, physiology, functions, and gene expression of zebrafish and human eyes. Furthermore, zebrafish embryos are easy to obtain, develop rapidly, and easily observed and manipulated. Therefore, zebrafish has become a good animal model for human ophthalmic diseases and provide new insights to further explore the pathogenesis of diseases and treatment method . This review introduces the ocular characteristics of zebrafish, the application of zebrafish animal models in ophthalmic diseases, and evaluation of ophthalmic drug efficacy and ocular toxicity of drugs. |
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