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李惠,赵菊梅,师长宏.基于肠道菌群的免疫调节策略用于结直肠癌联合治疗研究的进展[J].中国实验动物学报,2022,30(3):436~443.

基于肠道菌群的免疫调节策略用于结直肠癌联合治疗研究的进展

Research progress of intestinal flora immunomodulation combined therapy for colorectal cancer

投稿时间：2021-09-07

DOI：10. 3969 / j.issn.1005-4847. 2022. 03. 018

英文关键词:intestinal flora colorectal cancer immunoregulation combined treatment animal models

基金项目:

作者	单位	E-mail
李惠	1. 延安大学基础医学院,陕西延安 716000 2. 空军军医大学实验动物中心,西安 710032	1228559790@ qq. com
赵菊梅	延安大学基础医学院,陕西延安 716000	jmz2003. stu@ 163. com
师长宏	空军军医大学实验动物中心,西安 710032	changhong@ fmmu. edu. cn

Author Name	Affiliation	E-mail
LI Hui	1. Medical College of Yanan University, Yan’an 716000, China. 2. Laboratory Animal Center, the Air Force Medical University, Xi’an 710032	1228559790@ qq. com
ZHAO Jumei	Medical College of Yanan University, Yan’an 716000, China	jmz2003. stu@ 163. com
SHI Changhong	Laboratory Animal Center, the Air Force Medical University, Xi’an 710032	changhong@ fmmu. edu. cn

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中文摘要:

肠道菌群可形成特殊的免疫微环境,通过免疫调节机制影响结直肠癌的发生、发展和治疗。本文综述了肠道菌群用于结直肠癌免疫调节治疗的研究进展,回顾了肠道菌群与宿主免疫、肿瘤免疫的关系,重点分析了相关动物实验和临床试验的结果,总结了基于肠道菌群免疫调节联合疗法用于结直肠癌治疗的机制和策略,期望为结直肠癌的治疗提供新的参考。

英文摘要:

Intestinal flora form a specialized immune microenvironment that affects the occurrence and development of colorectal cancer through immunoregulation. Here, we review the research progress of intestinal flora in immune regulation therapy for colorectal cancer and summarize the relationship between intestinal flora and host or tumor immunity. Moreover, we analyzed the result of related animal experiments and clinical trials and introduce the mechanism and strategy of combination therapy based on intestinal flora immunomodulation for the treatment of colorectal cancer. Thus, this review may provide a reference for the treatment of colorectal cancer.

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