| 张晓蒙,马丙祥,周荣易,史文丽,李华伟.抽动障碍免疫相关动物模型研究进展[J].中国实验动物学报,2022,30(1):107~116. |
| 抽动障碍免疫相关动物模型研究进展 |
| Research progress on immune-related animal models of tic disorders |
| 投稿时间：2021-03-23 |
| DOI：10. 3969 / j.issn.1005-4847. 2022. 01. 014 |
| 中文关键词: 抽动障碍 免疫 动物模型 链球菌 抗体 |
| 英文关键词:tic disorders immune animal model Streptococcus antibody |
| 基金项目: |
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| 中文摘要: |
| 抽动障碍(tic disorders,TD)为儿童常见疾病,发病率不断上升,其病因及发病机制尚不明确,随着临床中感染与 TD 症状诱发和加重关系的认识及 TD 免疫炎症相关研究的进展,免疫异常也逐渐被认为是其重要致病因素及病理过程之一,建立 TD 免疫学动物模型是其免疫相关实验研究的基础,因此本文通过查阅国内外相关文献,系统介绍了国际上 TD 免疫相关动物模型的研究概况,并依据表面效度、结构效度和预测效度的国际动物模型评价标准对模型优劣进行比较分析,以期为国内 TD 的相关实验研究提供参考。 |
| 英文摘要: |
| Tic disorders (TD) are relatively common, with an increasing incidence, in children. The etiology and pathogenesis of TD are still unclear. With increased understanding of the relationship between infection, induction and exacerbation of TD symptoms in clinical practice, as well as research progress on TD-related immune inflammation, immune abnormalities are regarded as one of the important factors involved in the pathological processes of TD. The establishment of immunological TD animal models has provided the basis of immune-related experimental research. Therefore, this study systematically reviews the research status of TD immune-related animal models by consulting relevant domestic and foreign literature, and compares the advantages and disadvantages of models using international evaluation criteria of face validity, construct validity and predictive validity of animal models, to provide reference for domestic TD- related experimental research. |
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