Tic disorders (TD) are relatively common, with an increasing incidence, in children. The etiology and pathogenesis of TD are still unclear. With increased understanding of the relationship between infection, induction and exacerbation of TD symptoms in clinical practice, as well as research progress on TD-related immune inflammation, immune abnormalities are regarded as one of the important factors involved in the pathological processes of TD. The establishment of immunological TD animal models has provided the basis of immune-related experimental research. Therefore, this study systematically reviews the research status of TD immune-related animal models by consulting relevant domestic and foreign literature, and compares the advantages and disadvantages of models using international evaluation criteria of face validity, construct validity and predictive validity of animal models, to provide reference for domestic TD- related experimental research.