非酒精性脂肪肝炎动物模型的研究概况
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1.浙江中医药大学生命科学学院,杭州 310053; 2. 浙江中医药大学实验动物研究中心/ 比较医学研究所,杭州 310053

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Research progress on animal models of nonalcoholic steatohepatitis
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1.College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China. 2. Laboratory Animal Research Center/ Comparative Medical Research Institute, Zhejiang Chinese Medical University, Hangzhou 310053

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    摘要:

    随着全球代谢综合征患病率不断上升,非酒精性脂肪肝病(NAFLD)患病率也急剧上升,已是全球最常见的慢性肝疾病,包括单纯性脂肪肝、非酒精性脂肪性肝炎(NASH)、晚期纤维化、肝硬化和肝细胞癌。 而 NASH 是由单纯性脂肪肝发展至肝纤维化、肝硬化和肝癌的重要阶段,因此,预防和治疗 NASH 已成为一个研究焦点。 动物模型是研究疾病的发病机制、治疗药物的研发以及制定防治策略的重要环节。 目前已经开发的动物模型主要是模拟人类 NASH 的病理形态和临床特征,包括膳食动物模型、药物诱导动物模型和基因修饰动物模型,但这些模型均存在各自的优缺点。 本文就近年来 NASH 动物模型的研究及其应用情况进行总结,以供 NASH 研究者参考。

    Abstract:

    With the increasing global prevalence of metabolic syndrome, the prevalence of non-alcoholic fatty liver disease (NAFLD) has also risen sharply. NAFLD is the most common chronic liver disease in the world and includes simple steatosis and non-alcoholic fatty hepatitis ( NASH), advanced fibrosis, cirrhosis and hepatocellular carcinoma. NASH is an important stage from simple steatosis to fibrosis, cirrhosis and liver cancer. Therefore, the prevention and treatment of NASH has become an important research focus. Animal models are critical tools for studying the pathogenesis of diseases, research and development of therapeutic drugs, and formulating prevention and treatment strategies. The animal models that have been developed so far for NASH mainly simulate the pathological morphology and clinical characteristics of human NASH. These models include dietary animal models, drug-induced animal models and genetically modified animal models, and each model has its own advantages and disadvantages. In this paper, we review the research and applications of NASH animal models for NASH research.

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蔡江帆,陈民利.非酒精性脂肪肝炎动物模型的研究概况[J].中国实验动物学报,2021,29(1):128~136.

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  • 收稿日期:2020-06-30
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  • 在线发布日期: 2021-03-23
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