| 郑海香,丁明珠,张雨琪,施佳健,张璐,景月娥,王星.乙肝病毒相关肝细胞癌小鼠模型的构建和前沿应用现状[J].中国实验动物学报,2020,28(6):837~844. |
| 乙肝病毒相关肝细胞癌小鼠模型的构建和前沿应用现状 |
| Research progress of the mouse model of HBV-related hepatocellular carcinoma |
| 投稿时间：2020-05-27 |
| DOI：10. 3969 / j.issn.1005-4847. 2020. 06. 015 |
| 中文关键词: 乙型肝炎病毒 肝细胞癌 小鼠模型 肿瘤病毒 致瘤 |
| 英文关键词:hepatitis B virus hepatocellular carcinoma mouse model tumor virus oncogenesis |
| 基金项目: |
|
| 摘要点击次数: 96 |
| 全文下载次数: 40 |
| 中文摘要: |
| 病毒感染可引起世界范围内 12%左右癌症的发生,每年约有 130 万例患者死亡。 目前一个重要的瓶颈问题就是所有类型的肿瘤病毒均缺乏可广泛使用的体内研究模型。肝癌是全球第四大癌症相关死亡原因,其中肝细胞癌(hepatocellular carcinoma,HCC)占 80%,是最常见的类型。乙型肝炎病毒( hepatitis B virus,HBV)相关的 HCC 在我国尤为严重,占据所有病例的 60%以上。慢性 HBV 感染是发生肝癌最重要的危险因素,但目前对此类患者仍缺乏有效治愈手段。因此,明确 HBV 与宿主的互作方式及其致瘤机制是制定临床治疗策略的前提。近几十年来,HBV 病毒相关肝癌小鼠模型的建立和应用得以不断发展,伴随精准医学的进步出现了更多复杂的新模型和大量研究成果。本综述回顾分析现有基因工程小鼠和人源化小鼠在此类模型的构建方法等方面的特点,并进一步总结需应用于研究病毒致瘤机制时应特别注意的适用范围或优缺点。 |
| 英文摘要: |
| Viral infections cause approximately 12% of cancers worldwide and approximately 1. 3 million cancer- related deaths each year. However, representative in vivo models for all types of tumor viruses are lacking. Liver cancer is the fourth leading cause of cancer-related death in the world, and hepatocellular carcinoma (HCC) accounts for 80% of all liver cancer cases. Hepatitis B virus (HBV)-associated HCC is particularly a public health issue in China, which consists of more than 60% of domestic patients. Chronic HBV infection is the critical etiological factor for liver cancer. However, curable treatments for these patients are still lacking. The prerequisite for developing effective cancer drugs for HBV- associated HCC is to disrupt the mechanism of HBV interaction with the host. The mouse model of HBV-induced liver cancer has been remarkably advanced in recent decades, and multiple novel models have been developed by precision medicine. This review comprehensively summarizes the viral and oncogenic properties of in vivo models of HBV-induced HCC, with a focus on genetically engineered mouse and humanized mouse models. In addition, we discuss the benefits and caveats of each model and present a selection of the most important findings obtained from the respective systems. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
