Impaired immunity makes the body more susceptible to internal and external pathogenic factors, making people more susceptible and at higher risk for various diseases. To better conduct basic research for this special group, based on relevant studies performed in China and elsewhere in the past 10 years, this paper analyzes and summarizes the experimental animals, Methods and evaluation indexes involved in acquired secondary immunodeficiency models, and proposes that immunocompromised models can be integrated into future research on the modernization of traditional Chinese medicine.