Chronic obstructive pulmonary disease ( COPD) is characterized by incomplete reversible persistent progressive airflow limitations, and always presents acute exacerbations and serious complications. Establishing standardized animal models that are consistent with the clinical COPD characteristics of COPD is important for exploring its development, and morphological changes, as well as new therapeutic approaches. new therapeutic approaches. Many studies have been conducted on COPD, but there is no best method exists for constructing animal models of COPD. Here, we describe and compare the types of animals used to establish the COPD models and the advantages, and disadvantages, and clinical applications of each model.