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李敏,杨晨钰,傅超慧,熊一功,凌云.马齿苋 / 甘草 / 蒲公英及其复方改善 2 型糖尿病大鼠胰岛素抵抗的实验研究[J].中国实验动物学报,2020,28(4):517~524.
马齿苋 / 甘草 / 蒲公英及其复方改善 2 型糖尿病大鼠胰岛素抵抗的实验研究
Study of purslane / licorice / dandelion compound on insulin resistance in type 2 diabetic rats
投稿时间:2020-03-15  
DOI:10. 3969 / j.issn.1005-4847. 2020. 04. 012
中文关键词:  马齿苋  甘草  蒲公英  复方  降血糖  胰岛素抵抗  胰岛 β 细胞
英文关键词:purslane  glycyrrhiza  dandelion  compound  hypoglycemic  insulin resistance  islet β cell
基金项目:
作者单位E-mail
李敏 长沙医学院医学检验学院,长沙 410219 1273088185@ qq.com 
杨晨钰 长沙医学院医学检验学院,长沙 410219  
傅超慧 长沙医学院医学检验学院,长沙 410219  
熊一功 长沙医学院医学检验学院,长沙 410219  
凌云 长沙医学院医学检验学院,长沙 410219  
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中文摘要:
      目的 探讨马齿苋、甘草、蒲公英及其复方对 2 型糖尿病大鼠胰岛素抵抗的情况。 方法 小剂量链 脲佐菌素联合高糖高脂饮食建立 2 型糖尿病大鼠模型,造模成功后随机分为模型组、马齿苋组、甘草组、蒲公英组、 复方组及二甲双胍组并设正常组。 干预 4 周后,测定各组大鼠 FBG、TC、TG、HDL、LDL、FINS 数值的变化并计算 AI 值、ISI 值和 IRI 值。 取胰腺组织制成切片,染色后观察胰岛细胞的形态学变化。 结果 (1)各单方和复方干预组 体重与模型组比较均具有显著性差异(P < 0. 01),但效果不及二甲双胍。 (2)2 周时,各干预组大鼠 FBG 值与模型 组比较差异具有统计学意义(P < 0. 05);4 周时,各干预组大鼠 FBG 值均显著降低(P < 0. 01);干预 2 周以及干预 4 周复方组与二甲双胍组比较差异不具有统计学意义(P > 0. 05)。 (3)复方组和二甲双胍组糖负荷后 0. 5、1、2 h 血糖值均显著降低,但 2 h 血糖比较有统计学差异(P < 0. 05)。 (4)各干预组与模型组比较 ISI 值显著升高、IRI 值 显著降低(P < 0. 01),复方组 IRI 值与二甲双胍组比较差异无统计学意义(P > 0. 05)。 (5)复方组血清 TC、TG、LDL- C 值显著降低(P < 0. 01),HDH-C 值显著升高(P < 0. 01),同时发现二甲双胍组 TC、TG、HDH-C 和 LDL-C 水平与复方 组相似(P> 0. 05)。 (6)显微镜下观察发现复方组有修复增生表现,细胞排列均匀,大小一致,与二甲双胍组相似。 结论 马齿苋、甘草、蒲公英复方可调节糖脂代谢紊乱、修复胰岛 β 细胞从而改善胰岛素抵抗。 整体效果优于单方。
英文摘要:
      Objective To explore the effects of purslane, licorice, and dandelion compound on insulin resistance in type 2 diabetic rats. Methods Low-dose streptozotocin was combined with a high-sugar and high-fat diet to establish type 2 diabetic rats. After successful modeling, they were randomly divided into control ( normal), model, purslane, licorice, dandelion, compound, and metformin groups. After 4 weeks of intervention, Fasting blood glucose (FBG), Serum total cholesterol ( TC), Triglyceride ( TG), High-density lipoprotein ( HDL), Low-density lipoprotein ( LDL), and Fasting insulin (FINS) were measured in each group of rats. The changes in the values were calculated and Atherosclerosis index (AI), Insulin sensitivity index ( ISI), and Insulin resistance index ( IRI) values were calculated. The pancreatic tissue was cut into sections and the morphological changes were observed after staining. Results (1) The weight of each intervention group was significantly different from that of the model group (P< 0. 01), but the effect was not as good as metformin. (2)At 2 weeks, the FBG value of each intervention group was significantly lower than that of the model group (P< 0. 05); at 4 weeks, the FBG value of each intervention group was significantly lower (P< 0. 01), and there was no statistical significance between the compound group and the metformin group before and after 2 weeks and 4 weeks of intervention (P > 0. 05). ( 3) The 0. 5, 1, and 2 h blood sugar values of the compound and metformin groups were significantly lower after the glucose load, but there was a significant difference in 2-h blood glucose (P< 0. 05).(4) The ISI and IRI values of each intervention group were significantly higher and lower than those of the model group, respectively (P< 0. 01). (5) The levels of TC, TG, HDL-C, and LDL-C in the metformin group were similar to those in the compound group (P> 0. 05). (6)Microscopic observation revealed that the compound group underwent repair and proliferation, and the cells were arranged evenly and uniformly in size, similar to those in the metformin group. Conclusions Purslane, licorice, and dandelion compound can regulate glucose and lipid metabolism disorders, repair islet β cells, and thereby improve insulin resistance. The overall effect of combination treatment is better than that achieved with single treatment.
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