Miniature swine provide valuable research models for cardiovascular disease because their anatomical structure and physiological features are similar to those of human. Several studies have been published in which the miniature swine models of atherosclerosis have been established successfully. These models included general method of a high-fat diet plus balloon injury, as well as new method, such as gene editing-induced familial hypercholesteremia, and local intravascular delivery of lipid and inflammation factors. However, few of these models have been widely used. Long time consumption, high cost and huge heterogeneity among studies are problems that restrict application of these AS models. This article summarizes the breeds of miniature swine, the method used to establish atherosclerosis models, and the advantages and disadvantages of current models.