As an important experimental subject, experimental fish play an increasingly important role in life science, medicine, and water environment safety evaluation. At present, domestic production and research teams of experimental fish are expanding rapidly; the use of experimental fish is increasing yearly. However, the quality of the experimental fish is inconsistent, which may have a serious impact on the result of scientific experiments. Therefore, there is an urgent need to formulate experimental fish quality control standards to regulate and guide their production. This paper reviews the quality control of experimental fish and its research status, and provides suggestions and references for the development of experimental fish quality control standards.