Nickel is a metal that humans are often exposed to during production and daily life. It is an essential trace element in the human body, but in excess, it can harm the body. The exact mechanism of damage caused by excessive nickel exposure remains unclear, but is related to complex cellular and molecular mechanisms. The model of nickel-induced damages forms the basis for studying the mechanisms treatment of nickel-induced damages. The preparation characteristics of different models of nickel poisoning damage are similar, thus, experimental models should be selected according to the experimental purpose. This paper reviews several commonly used methods of modeling nickel poisoning.