Objective To investigate the effects of Tianma Xiongling Zhixuan tablets (TXZT) on the blood pressure of spontaneously hypertensive rats (SHRs) and renal hypertensive rats (RHRs). Methods Both SHRs and RHRs were used in the experiment, and the blood pressures of rats in each group were monitored. The left ventricular index (LVMI) of rats in each group was compared by the weighing method, the serum biochemical indexes were detected by ELISA, and the pathological changes of the heart, kidney, brain and aorta were observed using H&E staining. Results The high and middle doses of TXZT significantly lowered the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of RHRs and SHRs rats ( P < 0. 01 or 0. 05), whereas the low dose TXZT significantly lowered the SBP and DBP of SHRs rats ( P < 0. 01 or 0. 05), but had no significant effect on RHRs rats ( P >0. 05). Compared with the untreated model group, the LVMI of SHRs rats treated with TXZT was significantly decreased in the high-dose group ( P <0. 05), but not in other groups ( P >0. 05). Compared with the RHR model group, the values of creatine kinase (CK), creatinine (CREA) and serum urea nitrogen (BUN) values in the high dose TXZT-treated rats were significantly decreased; Lactate dehydrogenase(LDH), CK, CREA and BUN values were significantly decreased with the middle dose group, and BUN values were significantly decreased with the low dose ( P < 0. 01 or 0. 05). Compared with the SHR model group, the CK, CK, CREA and BUN values were decreased, but the difference was not statistically significant ( P >0. 05). Conclusions TXZT has good antihypertensive pharmacological effect on the two different rat models of hypertension, can keep the pulse pressure difference in a certain range, and has a sustaining and stable pharmacological action in regulating blood pressure. TXZT has good preventive and therapeutic effects on hypertension.