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刘林,李弘,王宇红,任卫琼,蔺晓源,李苏,柏正平.天麻芎苓止眩片对自发性与肾性高血压模型大鼠影响的比较研究[J].中国实验动物学报,2019,27(6):781~789.
天麻芎苓止眩片对自发性与肾性高血压模型大鼠影响的比较研究
Comparison of the effects of Tianma Xiongling Zhixuan Tablet on the blood pressure in spontaneously and renal hypertensive rats
投稿时间:2019-04-26  
DOI:10. 3969 / j.issn.1005-4847. 2019. 06. 015
中文关键词:  肾性高血压大鼠  自发性高血压大鼠  高血压  左心室指数
英文关键词:renal hypertensive rats  spontaneously hypertensive rats  hypertension  left ventricular mass index
基金项目:
作者单位E-mail
刘林 1. 湖南省中医药研究院, 长沙 410013
2. 湖南中医药大学第一附属医院,长沙 410007 
286410883@ qq.com 
李弘 湖南中医药大学, 长沙 410208  
王宇红 湖南中医药大学科学创新中心,长沙,410007  
任卫琼 湖南中医药大学第一附属医院,长沙 410007  
蔺晓源 湖南中医药大学第一附属医院,长沙 410007  
李苏 湖南中医药大学第一附属医院,长沙 410007  
柏正平 1. 湖南省中医药研究院, 长沙 410013
2. 湖南中医药大学, 长沙 410208 
bzp121@ 163.com 
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中文摘要:
      目的 探讨天麻芎苓止眩片对自发性高血压大鼠(spontaneously hypertensive rats,SHR)和肾性高血压大鼠(renal hypertensive rats,RHR)大鼠的影响?方法 采用RHR 和SHR 大鼠模型进行实验,连续给药4 周,观察比较各周大鼠血压值?左心室指数(left ventricular mass index,LVMI)?生化指标及HE 染色观察心脏?肾?脑?主动脉的病理形态变化?结果 天麻芎苓止眩片高?中剂量组能显著降低RHR 和SHR 大鼠的收缩压和舒张压( P <0. 01 或0. 05);低剂量组能够显著降低SHR 大鼠的收缩压和舒张压( P <0. 01 或0. 05),但对RHR 大鼠无显著的降压效果( P >0. 05)?与模型组比,SHR 高剂量组左室质量(left ventricular mass,LVM) 明显减小,差异具有统计学意义( P <0. 05),其他各给药组SHR 和RHR 大鼠左心室LVM 减轻,左心室指数减小,但差异不具有统计学意义( P >0. 05)?与RHR 模型组比,高剂量组能够显著降低RHR 大鼠尿素氮(BUN)?肌酐(CREB)?肌酸激酶(CK)值,中剂量组大鼠能够显著降低乳酸脱氢酶(LDH)?CK?CREA?BUN 值,低剂量组能够显著降低大鼠BUN 值,差异具有统计学意义( P <0. 05 或0. 01)?与SHR 模型组比,对SHR 大鼠CK?CREA?CREA?BUN 值有一定降低作用,但差异无统计学意义( P >0. 05)?结论 天麻芎苓止眩片对两种不同高血压大鼠模型均有显著降压效应,具有能够将脉压差保持在合理范围,持续稳定调节血压的作用特点?天麻芎苓止眩片对高血压具有较好的防治药理作用?
英文摘要:
      Objective To investigate the effects of Tianma Xiongling Zhixuan tablets (TXZT) on the blood pressure of spontaneously hypertensive rats (SHRs) and renal hypertensive rats (RHRs). Methods Both SHRs and RHRs were used in the experiment, and the blood pressures of rats in each group were monitored. The left ventricular index (LVMI) of rats in each group was compared by the weighing method, the serum biochemical indexes were detected by ELISA, and the pathological changes of the heart, kidney, brain and aorta were observed using H&E staining. Results The high and middle doses of TXZT significantly lowered the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of RHRs and SHRs rats ( P < 0. 01 or 0. 05), whereas the low dose TXZT significantly lowered the SBP and DBP of SHRs rats ( P < 0. 01 or 0. 05), but had no significant effect on RHRs rats ( P >0. 05). Compared with the untreated model group, the LVMI of SHRs rats treated with TXZT was significantly decreased in the high-dose group ( P <0. 05), but not in other groups ( P >0. 05). Compared with the RHR model group, the values of creatine kinase (CK), creatinine (CREA) and serum urea nitrogen (BUN) values in the high dose TXZT-treated rats were significantly decreased; Lactate dehydrogenase(LDH), CK, CREA and BUN values were significantly decreased with the middle dose group, and BUN values were significantly decreased with the low dose ( P < 0. 01 or 0. 05). Compared with the SHR model group, the CK, CK, CREA and BUN values were decreased, but the difference was not statistically significant ( P >0. 05). Conclusions TXZT has good antihypertensive pharmacological effect on the two different rat models of hypertension, can keep the pulse pressure difference in a certain range, and has a sustaining and stable pharmacological action in regulating blood pressure. TXZT has good preventive and therapeutic effects on hypertension.
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