缺血再灌注脊髓损伤动物造模研究进展
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(1. 甘肃中医药大学,兰州 730000; 2. 甘肃省中医院,兰州 730050)

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Q95-33

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Research progress in the establishment of animal models of spinal cord ischemia-reperfusion injury
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(1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.2. Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050)

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    摘要:

    脊髓损伤目前是脊柱外科研究的热点之一,其中对于脊髓缺血再灌注损伤(spinal cord ischemiareperfusioninjury,SCII)的研究一直是国内外的难点?目前用于研究脊髓缺血再灌注损伤的动物模型种类很多,但是仍缺乏一种最简便?最有效?最接近人类脊髓缺血再灌注损伤的模型?脊髓缺血再灌注损伤动物模型对于研究脊髓再灌注损伤相关疾病的病因病理机制分析,以及指导临床用药?研发新药方面有着至关重要的作用?因此本文通过查阅相关文献,对SCII 造模所用的动物种类?方法及运用研究现状进行综述,为建立简便有效并与人类SCII高度相似的模型提供参考?

    Abstract:

    Spinal cord injury is currently a major focus of research, and the study of spinal cord ischemicreperfusion injury (SCII) has been a major challenge worldwide. Many animal models are currently used to study SCII, but there is still a lack of the most simple, effective and most similar model to human SCII. An animal model of SCII plays avital role in the study of etiology and pathological mechaism of SCII related diseases, as well as in the guidance of clinical medication and the research and development of new drugs. This paper reviews the animal species, methods and applications used in SCII modeling in the relevant literature and describes the establishment of a simple, effective and highly similar model to human SCII.

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王雨榕,邓强,郭铁峰,彭冉东,李军杰,徐浩军.缺血再灌注脊髓损伤动物造模研究进展[J].中国实验动物学报,2019,27(5):658~662.

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  • 收稿日期:2019-03-11
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  • 在线发布日期: 2019-11-04
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