Objective To investigate the effects of selenium-enriched rice bran on the growth performance andantioxidant function in weaned rabbits. Methods Sixty 35-day-old weaned rabbits were randomly divided into three groups(n =20, 1∶1 male ∶female) and were fed with feed added ordinary rice bran, ordinary rice bran plus selenium-enrichedyeast or selenium-enriched rice bran for 30 days. Feed consumption was recorded daily and the rabbits were weighed at 0 d,5 d, 10 d, 15 d, 20 d, 25 d and 30 d, respectively. After 30 days, serum was collected and the content of blood glucose,uric acid, total protein, albumin, globulin, and albumin/ globulin ratio were measured by the IDEXX Catalyst Dx Analyzer.The activity of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and the content ofmalondialdehyde (MDA) were detected by assay kits. The liver, spleen and kidney were weighed, organ index wascalculated, and the selenium content in the kidney was determined. Results There were no significant differences in dailyweight gain, feed conversion ratio, organ index, kidney selenium content and the blood biochemical indexes among thethree groups ( P >0. 05). However, the activity of GSH-Px and SOD in the selenium-enriched rice bran group and theactivity of GSH-Px and CAT in the organic selenium group were significantly higher than that in the ordinary rice bran group( P <0. 05). The MDA content in these two groups was significantly lower than that of the ordinary rice bran group ( P <0. 05). In addition, the antioxidant capacity was comparable between the selenium-enriched rice bran group and organicselenium group. Conclusions Selenium in selenium-enriched rice bran plays a positive role in promoting growth andresisting oxidation in weaned rabbits, which is similar to the selenium in yeast. These findings indicate selenium-enriched rice bran can be used as a selenium source of feed for weaned rabbits.