Liver is the main target organ for colorectal cancer metastasis. Liver metastasis is also the main cause of death in patients with colorectal cancer. Recent studies have shown that liver metastasis of colorectal cancer patient-derived tumor xenograft (PDTX) can better replicate the clinical characteristics of clinical tumors colon cancer. At present, the primary models used are the orthotopic tumor xenograft model and ectopic tumor xenograft model. To provide a reference for experimental modeling, this paper reviews PDTX animal models for colorectal cancer liver metastasis and their application range.