欢迎访问中国实验动物学报网站！

周荣易,党伟利,周正,李华伟,张晰.孤独症谱系障碍动物模型研究进展[J].中国实验动物学报,2019,27(3):380~386.

孤独症谱系障碍动物模型研究进展

Advances in research of animal models of autism spectrum disorders

投稿时间：2018-11-20

DOI：10. 3969 / j.issn.1005-4847. 2019. 03. 017

英文关键词:autism spectrum disorders animal model BTBR model valproic acid

基金项目:

作者	单位	E-mail
周荣易	河南中医药大学第一附属医院儿科,河南省中西医结合儿童医院儿童脑病诊疗康复中心, 郑州 450000	zhourongyitcm@ sina.com
党伟利	河南中医药大学第一附属医院儿科,河南省中西医结合儿童医院儿童脑病诊疗康复中心, 郑州 450000	dangweili142@ 163.com
周正	河南中医药大学第一附属医院儿科,河南省中西医结合儿童医院儿童脑病诊疗康复中心, 郑州 450000
李华伟	河南中医药大学第一附属医院儿科,河南省中西医结合儿童医院儿童脑病诊疗康复中心, 郑州 450000
张晰	河南中医药大学第一附属医院儿科,河南省中西医结合儿童医院儿童脑病诊疗康复中心, 郑州 450000

摘要点击次数: 146

全文下载次数: 41

中文摘要:

孤独症谱系障碍(austim spectrum disorder, ASD)近来全球发病率不断升高,但该病的病因及发病机制尚未明确,从动物模型出发探索疾病的病因及发病机制是必然趋势?国内对本病的认识及动物模型研究相对滞后,国际上ASD 动物模型可大概分为基因遗传模型?特发性动物模型及调控环境因素动物模型三大类,其中基因遗传模型较多,但研究针对性过强;特发性模型中的BTBR 模型及调控环境因素模型中的丙戊酸诱导模型能够较好地呈现ASD 典型临床症状及部分病理学特征,为当前主要应用模型?ASD 的研究尚缺乏完整符合结构有效性?表面有效性?预测有效性的理想动物模型?

英文摘要:

The global incidence of autism spectrum disorders (ASDs) is increasing. However, the etiology andpathogenesis of ASDs are not known, and animal models are used to disclose them. Understanding of ASDs and their studyusing animal models are relatively new in China. The internationally commonly used animal models of ASD can be dividedbroadly into three categories: genetic animal models, idiomatic animal models, and animal models developed byenvironmental interventions. Among them, the genetic animal model has a high profile but a small scope of application. TheBTBR mouse model (which is an idiomatic animal model) and the animal models developed by environmental interventionsusing valproic acid can present typical clinical symptoms and some pathologic features of ASDs better than those elicited byother models. These two models should be selected before research is commenced. Nevertheless, research into ASDs lacks an “ideal” animal model that meets all the “three types of validity”: structural, surface, and predictive validities.

查看全文查看/发表评论下载PDF阅读器

关闭