| 马畅,郭健敏,谢松强,杨威.白血病小鼠模型的建立与应用进展[J].中国实验动物学报,2019,27(2):266~270. |
| 白血病小鼠模型的建立与应用进展 |
| Research progress in establishment and application of mouse models of leukemia |
| 投稿时间：2018-07-15 |
| DOI：10. 3969 / j.issn.1005-4847. 2019. 02. 022 |
| 中文关键词: 急性白血病 小鼠 模型 |
| 英文关键词:acute leukemia mouse model |
| 基金项目: |
| 作者 | 单位 | E-mail | | 马畅 | 1. 广东省生物资源应用研究所,广东省动物保护与资源利用重点实验室,广东省野生动物保护与利用公共实验室,广州 510260
2. 河南大学药学院,河南开封 475000
3. 广东莱恩医药研究院有限公司重点实验室,广州 510990 | 874342040@ qq.com | | 郭健敏 | 1. 广东省生物资源应用研究所,广东省动物保护与资源利用重点实验室,广东省野生动物保护与利用公共实验室,广州 510260
2. 广东莱恩医药研究院有限公司重点实验室,广州 510990 | | | 谢松强 | 河南大学药学院,河南开封 475000 | xiesq@ henu.edu.cn | | 杨威 | 1. 广东省生物资源应用研究所,广东省动物保护与资源利用重点实验室,广东省野生动物保护与利用公共实验室,广州 510260
2. 广东莱恩医药研究院有限公司重点实验室,广州 510990 | yangwei0719@ 163.com |
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| Author Name | Affiliation | E-mail | | MA Chang | 1.Guangdong Institute of Biological Resources Application, Guangdong Provincial Key Laboratory ofAnimal Protection and Resource Utilization, Guangdong Provincial Public Laboratory for WildlifeConservation and Utilization, Guangzhou 510260, China. 2. School of Pharmacy, Henan University,Kaifeng 475000. 3. Guangdong Lewwin Medicine Research Institute Co., Ltd., Guangzhou 510990 | 874342040@ qq.com | | GUO Jianmin | 1.Guangdong Institute of Biological Resources Application, Guangdong Provincial Key Laboratory ofAnimal Protection and Resource Utilization, Guangdong Provincial Public Laboratory for WildlifeConservation and Utilization, Guangzhou 510260, China.2. Guangdong Lewwin Medicine Research Institute Co., Ltd., Guangzhou 510990 | | | XIE Songqiang | School of Pharmacy, Henan University,Kaifeng 475000. | xiesq@ henu.edu.cn | | YANG Wei | 1.Guangdong Institute of Biological Resources Application, Guangdong Provincial Key Laboratory ofAnimal Protection and Resource Utilization, Guangdong Provincial Public Laboratory for WildlifeConservation and Utilization, Guangzhou 510260, China.2. Guangdong Lewwin Medicine Research Institute Co., Ltd., Guangzhou 510990 | yangwei0719@ 163.com |
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| 中文摘要: |
| 白血病又被称为“血癌”,其发病的根本特征是白血病细胞在骨髓及其他造血组织中呈恶性?无限制地增生,浸润全身各组织和脏器,产生不同症状,使患者易发生严重的感染或继发性的败血症?引起出血?肠功能衰竭?高尿酸血症等,严重威胁到患者的生命?因此白血病治疗的研究至关重要?利用实验动物进行各种疾病?药物疗效实验的研究,是医药领域发展的一个重要方面?对于白血病的研究,小鼠在生物学?遗传学?造血系统等方面与人类相似,因此是较为理想的动物白血病模型?本文对近五年来国内外研究常用的小鼠白血病模型进行综述? |
| 英文摘要: |
| Leukemia is often referred to as a “blood cancer”. The basic characteristic of the disease is thatleukemic cells become malignant and cause unrestricted proliferation in the bone marrow and other hematopoietic tissues.Then, these cells infiltrate all tissues and organs of the body causing various symptoms, and make patients prone to seriousinfections and life-threatening complications such as sepsis, hemorrhage, intestinal failure or hyperuricemia. Therefore,research on the treatment of leukemia using laboratory animal models is of great significance. For the study of leukemia,mice are similar to humans in terms of biology, genetics, and hematopoietic systems, and are, therefore, ideal models forleukemia research. This article reviews the mouse models of leukemia used commonly in studies both in China and abroad in the past 5 years. |
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