Laboratory Animals are widely used in scientific research, and experimental miniature swine are getting more and more attention in the field of medical research around the world. In China, the resources of miniature swine are very rich, different species have their own characteristics and their genetic characters are stable. In recent years, the research on experimental miniature swine is in a rapid development stage in China, and the production and usage are increasing year by year. The development of experimental miniature swine in China has the unique advantages of natural closed group characteristics and high inbreeding. The main development trend of experimental miniature swine in China is strain-systematization, standardization, large-scale and industrialization. The current problems faced by the development of experimental miniature swine in China are mainly reflected in three aspects: weak protection, considerable resistance to development, and few of finished strains. Breeding the strain of experimental miniature swine with different characteristics in China requires an increase in investment, using advanced science and technology such as gene editing and animal cloning technology to accelerate the process of orientational breeding of miniature swine.