生长激素受体基因敲除小鼠模型
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(1. 大连医科大学重大疾病基因工程模式动物研究所,基因工程模式动物国际联合研究中心,辽宁 大连 116044; 2. 吉林大学附属第一医院干部病房,长春 130000)

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Q95-33

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Overview of growth hormone receptor knockout mouse models
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(1. Institute of Genome Engineered Animal Models for Human Disease, National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian Liaoning 116044, China; 2. VIP Ward, First Hospital of Jilin University, Changchun 130000)

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    摘要:

    由脑垂体合成并分泌的生长激素(GH)不仅控制机体生长发育,还在许多代谢疾病中起关键调控作用?GH 的生物学功能通过与其表面受体(GHR)结合而启动,基于分子生物学技术构建各种GHR 敲除小鼠模型成为揭示GH 调控机制的基础?利用Cre ?LoxP 重组酶系统,迄今已在小鼠全身或组织特异性(如肝,骨骼肌,脂肪,巨噬细胞和胰岛β 细胞等)敲除ghr 基因,并从中探索GH/ GHR 信号转导及其与其他信号通路的相互作用?本文综述并讨论了这些ghr 基因敲除小鼠模型的表型特征和应用,从不同方面介绍了GH/ GHR 相关信号通路研究现状?

    Abstract:

    Growth hormone (GH) is synthesized and released by somatotrophic cells in the pituitary gland. As well as functions in growth and development, GH is also important in many metabolic diseases. The biological functions of GH are initiated by ligand binding to the surface receptor,growth hormone receptor (GHR). Rapid advances in molecular technology have enabled construction of various GHR knockout mice models to examine the mechanisms of action of GH. Using a Cre ?LoxP recombinase system, the mouse GHR has also been successfully knocked out systemically and tissue?specifically, including in the liver, skeletal muscle, adipose tissues, macrophages, and pancreatic islet β?cells. This has provided a unique platform for studying GH/ GHR signal transduction and its interactions with other signaling pathways. In this brief review, we discuss the phenotypic characteristics and applications of these GHR knockout mouse models.

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王小双,米艾,孙捷,王丹,曾丽,冉丽媛,吴英杰.生长激素受体基因敲除小鼠模型[J].中国实验动物学报,2018,26(5):662~666.

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  • 收稿日期:2018-04-13
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  • 在线发布日期: 2018-11-09
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