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孙昌华,祝清芬,王娜,赵德明.南极磷虾油辅助降血脂预防作用与治疗作用的比较[J].中国实验动物学报,2018,26(4):480~488.
南极磷虾油辅助降血脂预防作用与治疗作用的比较
Comparison of the auxiliary preventive and therapeutic lipid?lowering effects of Antarctic krill oil on rat models of hyperlipidemia
投稿时间:2018-03-20  
DOI:10.3969/j. issn. 1005 - 4847. 2018. 04. 012
中文关键词:  南极磷虾油  辅助降血脂  高血脂症  SD 大鼠
英文关键词:Antarctic krill oil  auxiliary lipid?lowering effect  hyperlipidemia  SD rat
基金项目:
作者单位E-mail
孙昌华 1. 中国农业大学动物医学院,北京 100193
2. 山东省食品药品检验研究院,济南 250101 
sunchanghuavip@163. com 
祝清芬 山东省食品药品检验研究院,济南 250101  
王娜 济南极源生物科技有限公司,济南25000  
赵德明 中国农业大学动物医学院,北京 100193 zhaodm@ cau. edu. cn 
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中文摘要:
      目的 研究比较南极磷虾油对实验性高血脂大鼠预防和治疗给药辅助降血脂作用效果?方法 喂养高脂肪高胆固醇饲料建立SD 大鼠高脂血症模型?预防组于造模前给予磷虾油14 d 及造模期间继续给予磷虾油12 d?治疗组则于造模期间给予高脂肪胆固醇饲料和磷虾油12 d?造模结束后采血检测大鼠血清总胆固醇 (TC)?甘油三脂(TG)?高密度脂蛋白胆固醇(HDL?C)及低密度脂蛋白胆固醇(LDL?C),病理学检查观察各组肝组织的病变?分析比较磷虾油对于高血脂大鼠辅助降血脂的预防和治疗的功效?结果 南极磷虾油预防给药组大鼠的血清TC 和LDL?C 显著降低( P < 0. 05),肝组织的脂肪变性程度较轻,但对血清TG?HDL?C 的影响不明显( P > 0. 05)?虾油治疗给药未见大鼠血清TC?TG?HDL?C?LDL?C 明显下降( P > 0. 05),辅助降血脂作用效果不明显?结论 南极磷虾油辅助降血脂作用预防性给药效果明显,具有显著降低血脂TC 的作用?
英文摘要:
      Objective To compare and analyze the auxiliary preventive and therapeutic lipid?lowering effects of Antarctic krill oil on high?fat high?cholesterol diet?induced hyperlipidemia rat models. Methods Forty?eight 5 - 6?week old SPF male Sprague?Dawley rats were divided into four groups: the blank normal group, hyperlipidemia model group, krill oil prevention group and krill oil treatment group. The rat model of hyperlipidemia was established by high?fat high cholesterol diet feeding. The krill oil prevention group was continuously administered krill oil for 14 days before and 12 days during the establishment of hyperlipidemia models. Meanwhile,the krill oil treatment group received krill oil for 12 days only during the hyperlipidemia modeling period. Serum total cholesterol (TC), triglyceride (TG), high?density lipoprotein cholesterol (HDL?C), and low?density lipoprotein cholesterol (LDL?C) in the rats were measured and pathological examination of liver tissues was performed to assess and compare the preventive and therapeutic effects of krill oil on hyperlipidemia and hypercholesterolemia in the rats. Results The preventive administration of krill oil significantly reduced serum TC and LDL?C ( P < 0. 05), paralleled by the milder fatty degeneration of liver tissues, while no significant changes of serum TG and HDL?C ( P > 0. 05). After therapeutic administration of Antarctic krill oil, there was no significant difference in serum concentration of TC, TG, HDL?C and LDL?C ( P > 0. 05) compared with the model group, and no significant auxiliary lipid?lowering effect was observed on the hyperlipidemia rats. Conclusions There is a significant auxiliary lipid?lowering effect and reducing serum total cholesterol after preventive administration of Antarctic krill oil.
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