The symbiotic bacterial species Wolbachia pipientis is a maternally inherited, intracellular parasitic microbe common to arthropod species (including most insects) and some nematodes. This bacteria manipulates the reproduction of its hosts by different mechanisms, including cytoplasmic incompatibility, parthenogenesis inducing, malekilling, feminization and increase female fecundity. In this paper, previous studies on the interactions between Wolbachia and Drosophila is briefly surveyed and discussed.