血友病关节软骨发病机制的研究进展
作者:
作者单位:

1. 华北理工大学,河北 唐山 063000;2. 华北理工大学附属医院,河北 唐山 063000

作者简介:

通讯作者:

中图分类号:

基金项目:


Research progress on the pathogenesis of articular cartilage in hemophilia
Author:
Affiliation:

1. North China University of Science and Technology, Tangshan 063000, China. 2. the Affiliated Hospital of North China University of Science and Technology, Tangshan 063000

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    本文就血友病关节软骨发病机制的研究进展做一综述,以期进一步理解血友病软骨损伤发生发展的独特机制,旨在为修复软骨新的治疗手段提供新思路。 遴选 PubMed、Web of Science、SpringerLink、Google Scholar等英文数据库和中国知网、维普网、万方网等中文数据库,英文检索关键词为“ hemophilic、Joint bleeding、cartilage、Pathogenesis、cytokine、immunocyte、iron、synovitis、blood、plasmin、signaling pathway”,中文检索关键词为“血友病、关节出血、软骨、发病机制、细胞因子、免疫细胞、铁、滑膜炎、血液、纤溶酶、信号通路”,根据入选标准及排除标准,检索自 1981 年 1 月~2022 年 3 月血友病关节软骨病理生理学相关度较高的文献,排除内容陈旧或重复性文献,最终纳入相关文献 60 篇多种细胞因子、免疫细胞、铁离子沉积、慢性滑膜炎、血液、纤溶酶、信号通路等均会导致软骨细胞凋亡,从而导致血友病软骨损伤,其中铁离子沉积是造成血友病软骨损伤的关键;各个影响因素在发病之间相互联系,复杂交错,如何调控各个影响因素对关节软骨的损害,有望成为修复软骨的重要方法。

    Abstract:

    This review summarizes the research progress of joint cartilage pathogenesis in hemophilia patients to further understand the unique mechanism of the development of cartilage damage to the occurrence of blood friends, and aims to provide new ideas to repair cartilage. English language databases, such as PubMed, Web of Science, SpringerLink, Google Scholar and Chinese language databases, such as CNKI, VIP and Wanfang, were selected. The English search key words were hemophilic, Joint bleeding, cartilage, Pathogenesis, cytokine, immunocyte, iron, synovitis, blood, plasma and signaling pathway. The Chinese search key words were hemophilia, joint hemorrhage, cartilage, pathogenesis, cytokines, immune cells, iron, synovitis, blood, plasmin and signal pathway. In accordance with the inclusion and exclusion criteria, literature with a high correlation of joint soft bone pathophysiology of hemophilia from January 1981 to March 2022 were searched, older or repetitive literature was excluded, and 60 related articles were finally included. and Conclusion Various cytokines, immune cells, iron ion deposition, chronic synovitis, blood, plasmin, and signaling pathways lead to chondrocyte apoptosis, leading to hemophilia cartilage injury in which iron ion deposition is critical for hemophiliac cartilage injury. Various influencing factors are interrelated and complex. How to regulate the damage of various influencing factors in articular cartilage is expected to become an important method to repair cartilage.

    参考文献
    相似文献
    引证文献
引用本文

陈爽,闫振宇.血友病关节软骨发病机制的研究进展[J].中国实验动物学报,2022,30(7):996~1002.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2022-03-12
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2023-03-10
  • 出版日期:
防诈骗提示!请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭