肠道菌群与肠屏障互作影响动脉粥样硬化形成的研究进展
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1. 浙江中医药大学 药学院,杭州 310053;2. 浙江中医药大学 动物实验研究中心/ 比较医学研究所,杭州 310053

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Research progress in the interaction between intestinal flora and the intestinal barrier in atherosclerosis
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1. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. 2. Laboratory Animal Research Center/ Institute of Comparative Medicine, Zhejiang Chinese Medical University, Hangzhou 310053

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    摘要:

    动脉粥样硬化(atherosclerosis,AS)是一种慢性炎症代谢性疾病,与高血压、高血脂、高血糖、高尿酸等危险因素联系密切。 肠道屏障功能对维持人体肠道功能稳态发挥着重要调节作用,肠道菌群是肠道屏障的重要组成部分,肠道菌群紊乱会导致肠道屏障受损、肠道通透性增加,同时菌群相关产物如脂多糖( lipopolysaccharide,LPS)、短链脂肪酸(short chain fatty acid,SCFAs)、胆汁酸(bile acids,BAs)、氧化三甲胺(trimethylamine oxide,TMAO)等发生改变,可引发机体炎症反应、氧化应激等不良反应,影响 AS 的发生发展。 本文就肠道菌群与肠屏障互作对于 AS 的形成及其危险因素的影响作一综述,为研究和防治 AS 提供参考。

    Abstract:

    Atherosclerosis (AS) is a chronic inflammatory metabolic disease closely associated with risk factors such as hypertension, hyperlipidemia, hyperglycemia, and hyperuricemia. The intestinal barrier function plays an important regulatory role in maintaining intestinal homeostasis, and intestinal flora is an important component. Disturbance of intestinal flora can lead to intestinal barrier damage and an increase of intestinal permeability. The related products, such as lipopolysaccharide, short chain fatty acids, bile acids, and trimethylamine oxide change and can cause inflammation, oxidative stress, and other adverse reactions that then affect the occurrence and development of AS. In this article, we review the interaction between intestinal flora and the intestinal barrier in AS development and its risk factors, and provide a reference for the study and prevention of AS.

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徐雁云,陈民利.肠道菌群与肠屏障互作影响动脉粥样硬化形成的研究进展[J].中国实验动物学报,2022,30(7):973~982.

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  • 收稿日期:2022-05-11
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  • 在线发布日期: 2023-03-10
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